Value of endoscopic resection on duodenal space-occupying lesions

Abstract

Objective To assess the clinical value and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for duodenal lesions. Methods The data of 12 patients with duodenal space-occupying lesions underwent EMR or ESD from January 2010 to December 2015 in Chinese PLA General Hospital were retrospectively analysed. Results All patients received operation, including 9 male and 3 female with mean age of 50.0 years(33.0-62.0 years). There were 8 lesions in duodenal bulb and 4 in descending part.The mean diameter of the lesions was 1.2 cm (0.5-3.0 cm). Three lesions were originated from mucosa, of which 2 were high-grade intraepithelial neoplasia and 1 was villous/tubular adenoma. Nine lesions were located in submucosa, including 3 cases of neuroendocrine neoplasm, 1 case of stromal tumor, 1 liomyoma case, 1 lipoma case, 1 case of Brunner glands adenoma, 1 case of ectopic pancreas, and 1 inflammatory lesion. One patient had perforation with rate of 8.3%(1/12) and was recovered after conserved treatment. The bleeding was very little during operation. No infection or stenosis happened. The mean hospitalized time was 6.0 days (1.0-12.0 days) after operation. No recurrence was found during 23.8 months(3.0-73.0 months) of follow-up. Conclusion EMR and ESD are effective and safe for treatment of duodenal space-occupying lesions. Key words: Therapeutic endoscopy; Endoscopic mucosal resection; Endoscopic submucosal dissection; Duodenal lesions