Value of combined multi-modal ultrasound detections on diagnosis of breast nodules

Abstract

Objective To explore the value of combined a variety of imaging modalities of ultrasound on diagnosis of breast nodules. Methods By color Doppler flow imaging (CDFI), virtual touch tissue imaging (VTI), virtual touch tissue quantification (VTQ), Contrast enhanced ultrasound (CEUS) and other imaging modalities, 307 breast lesions from 261 patients were detected. The results were analyzed and were compared with the postoperative pathological findings. Results 307 breast nodules included 186 benign and 121 vicious. The sensitivity, specificity and accuracy of CDFI on diagnosis of breast disease were 71.2 %, 52.3 % and 73.4 %, respectively, those of VTI were 66.9 %, 41.4 % and 51.1 %, respectively, those of VTQ shear wave velocity Vs were 83.5 %, 88.2 % and 86.3 %, respectively, those of CEUS were 85.1 %, 89.2 % and 87.6 %, respectively, and those of combined variety of imaging modalities were 94.2 %, 95.7 % and 93.8 %, respectively. The area under the curve of CDFI, VTI, VTQ, CEUS and combined multi-modal group diagnostic model were 0.877, 0.596, 0.889, 0.907 and 0.920, respectively. Among of CDFI, VTI, VTQ and CEUS, there were statistical differences (P 0.05). Conclusion Combined multi-modal ultrasound detection is complementary to improve the diagnostic accuracy on breast diseases. Key words: Breast nodules; Multi-modal; Ultrasonography; Diagnosis