Abstract
Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis.
Highlights
Sepsis is a complex process characterized by uncontrolled systemic inflammation that may eventually lead to multiorgan dysfunction and even death [1].Endothelin-1 (ET-1) is the main isoform of the endothelin family, which have important roles in a wide range of diseases affecting the vascular system, kidney, heart, and lungs
Excessive release of proinflammatory mediators which are induced by endotoxin like tumor necrosis factor-alpha (TNF-alpha) and reactive oxygen species (ROS) causes systemic inflammatory response during sepsis [4]
ET-1, TNF-alpha, and MDA levels and superoxide dismutase (SOD) activities for all groups are presented in Figures 1–4 as mean ± SD
Summary
Sepsis is a complex process characterized by uncontrolled systemic inflammation that may eventually lead to multiorgan dysfunction and even death [1].Endothelin-1 (ET-1) is the main isoform of the endothelin family, which have important roles in a wide range of diseases affecting the vascular system, kidney, heart, and lungs. TNF-alpha has important roles in the development of organ dysfunction related to sepsis It induces organ damage through activation of neutrophils and endothelial cells as well as coagulation abnormalities in patients with sepsis. Based on this knowledge, inhibition of TNF-α might be critical for treating septic organ dysfunction [5, 6]. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Treatment with CAPE can be used to avoid devastating effects of sepsis
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