Abstract

Objective To investigate the plasma levels of BNP and NT-proBNP in children with Kawasaki disease (KD) and study theassociation of these markers with coronary artery damage. Methods Seventy KD patients were divided into coronary artery injury group and non-coronary artery injury group. The plasma levels of BNP and NT-proBNP were detected with colloidal gold and enzyme-linked immunosorbent assay respectively. Results There were 14 cases of coronary artery injury, plasma NT-proBNP at acutephase was higher in 12 cases (85.7%), and plasma BNP values were higher in 3 cases (21.4%), there were significant differences (P<0.05). In coronary artery injury group, NT-proBNP levels were significantly higher in acute and recovery phases in coronary artery injury group than those in non-coronary artery injury group (P<0.05). Compared with non-coronary artery injury group, the BNP levels were not significantly changed in acute and recovery phases in coronary artery injury group. Conclusions Compared with BNP, abnormal increase of plasma NT-proBNP indicates the development of coronaryartery injury in KD patients. Key words: Kawasaki disease; Coronary artery injury; NT-terminal pro-brain natriuretic peptide; Brain natriuretic peptide

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