Abstract
BackgroundObesity is a disease characterized by much fat accumulation and abnormal distribution, which was related to cardiovascular diseases, diabetes mellitus (DM) and muscular skeletal diseases. The aim of this study was to evaluate the usefulness of appendicular skeletal muscle mass to total body fat ratio (ASM/TBF) in screening for the risk of obesity in elderly people.MethodsA prospective study was carried out with 446 participants (non-obese elderly people with body mass index (BMI) < 28 kg/m2) who underwent baseline and an average around 2.2-year follow-up health check-up examinations.ResultsThe mean age at baseline was 63.6 years. The incidence of new obesity was 5.4% during follow-up. Linear regression demonstrated that baseline ASM/TBFs were negatively correlated with follow-up BMIs in both men and women (β = − 1.147 (− 1.463—-0.831) for men and − 4.727 (− 5.761—-3.692) for women). The cut-off points of baseline ASM/TBF in elderly people for obesity were 1.24 in men and 0.90 in women which were identified by Classification and Regression Tree (CART). Logistic regression showed that both men and women with decreased ASM/TBF had higher risks of obesity over the follow-up period (Relative Risk (RRs) = 5.664 (1.879–17.074) for men and 34.856 (3.930–309.153) for women).ConclusionsElderly people with a low ASM/TBF had a higher risk of new obesity, which suggested that ASM/TBF should be considered in obesity management in the elderly.
Highlights
Obesity is a disease characterized by much fat accumulation and abnormal distribution, which was related to cardiovascular diseases, diabetes mellitus (DM) and muscular skeletal diseases
Another study suggested that appendicular skeletal muscle mass (ASM)/total body fat (TBF) was more related to cardio-metabolic and functional abnormalities than TBF/weight, which indicated that ASM/TBF was worth further exploring [9]
Effect of baseline ASM/TBF on follow-up BMI Linear regression demonstrated that baseline ASM/TBFs were negatively correlated with follow-up body mass indexes (BMIs) in both men and women (β = − 1.147 for men and − 4.727 for women even after adjusted for age, albumin and DM history; all P < 0.001, Table 2)
Summary
Obesity is a disease characterized by much fat accumulation and abnormal distribution, which was related to cardiovascular diseases, diabetes mellitus (DM) and muscular skeletal diseases. The aim of this study was to evaluate the usefulness of appendicular skeletal muscle mass to total body fat ratio (ASM/TBF) in screening for the risk of obesity in elderly people. The close relationship between appendicular skeletal muscle mass (ASM) / total body fat (TBF) and sarcopenia obesity, which was defined by top TBF quartile, has been well recognized in previous studies [6]. Zhang et al BMC Geriatrics (2020) 20:143 the association between this ratio and new obesity has not been adequately investigated. It is still not known whether ASM/TBF has significant value to access the risk of obesity. There was no agreement about the cut-off points for ASM/TBF to diagnose obesity let alone predict it
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