Value of ~(99)Tc~m-NOET gated myocardial perfusion on patients with coronary heart disease

Abstract

Objective To predict the value of ~(99)Tc~m-bis(N-ethoxy-N-ethyl-dithiocarbamato)nitridotechnetium(~(99)Tc~m-NOET)gated myocardial perfusion SPECT on detecting coronary artery disease.Methods For evaluation of suspected coronary artery disease,45 men and 11 women(mean age,45.9±12.4)underwent the rest gated SPECT.SPECT imasing was began 1 hour after intravenous injection of ~(99)Tc~m-NOET at rest.The SPECT images acquired end diastolic volume(EDV),end systolic volume(ESV),left ventricular ejection fraction(LVEF).And were analyzed from end systolicregional perfusion.ejection fraction,motion and thickening by 4 polar maps.All of them underwent coronary angiography(≥50%luminal diameter stenosis was considered significant coronary stenosis).Results Sensitivity and specificity of ~(99)Tc~m-NOET rest gated myocardial perfusion SPECT for detecting coronary artery disease were 68.42%and83.33%,respectively.There wag statistically significant difference for function parameters(EDV,ESV and LVEF)between myocardial infarction group[(129.32±9.14)ml,(80.97±9.49)ml,(40.15±3.28)%]and control group[(80.91±3.12)ml,(30.12±1.79)ml,(63.51±1.04)%,EDV: F=22.103,ESV: F=32.277,LVEF: F=42.604,P＜0.01].There were not significant difference between control group and ischemic group[(70.83±3.46)ml,(25.13±2.85)ml,(65.55±2.62)%].In myocardial infarction group left ventricular were divided into 460 segments,and 209 segments were abnormal simultaneously in regional perfusion,ejection fraction,motion and thickening by 4 polar maps.Conclusions ~(99)Tc~m-NOET rest SPECT is clinically feasible in detecting coronary artery disease.Global left ventricular function parameters have higher values in assessment of myocardial infarction and not have advantage in diagnose of coronary artery disease.In the patients with myocardial infarction,not matching between the regional perfusion and wall contraction function is useful to assessment of myocardial viability. Key words: Coronary disease; Tomography,emission-computed,single-photon ~(99)Tc~m-NOET; Gated myocardial perfusion imaging