Abstract
Background: Anal fissure is a linear tear in the distal anal canal, associated with spasm of internal anal sphincter. Acute anal pain with bleeding on defecation are the main symptoms. Different types of chemical treatment to relax the sphincteric muscles have tried. Objective: Assess the efficacy, side effects and recurrence rate of 0.2% glycerile trinitrate ointment (GTN) and 2% diltiazim hydrochloride gel (DTZ) in treatment of acute anal fissure. Methods: A prospective randomized trial of 112 patient with acute anal fissure over 1.5 years period at Al-Kindy Teaching Hospital. The diagnosis was entirely clinical. Setting of inclusion and exclusion criteria, ethical consideration respected.
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