Value and forecast heart failure of seroconcenttrations of NGAL and NT-proBNP in patients with acute coronary syndrome at Can Tho University of Medicine and Pharmacy Hospital

Abstract

Background: Acute coronary syndrome is a serious, emergency coronary artery disease event. Levels of neutrophil gelatinase-binding lipocalin (NGAL), a urinary sodium-reducing peptide (NT-proBNP) in the blood released during myocardial injury, thus correlate with heart failure events in patients with the acute coronary syndrome. Objectives: To determine the value of serum NGAL and NT-proBNP levels and predictability of heart failure events in patients with the acute coronary syndrome at Can Tho University of Medicine and Pharmacy Hospital in 2021-2022. Materials and methods: A cross-sectional descriptive study was conducted on 58 patients were diagnosed with acute coronary syndrome at the Department of Interventional Cardiology – Neurology, Can Tho University of Medicine and Pharmacy Hospital. Results: Mean values of NGAL was 56.5±15.7ng/mL and NT-proBNP was 5303.4±1172pg/mL. The value of NGAL concentration in predicting heart failure events, at the cut-off point of 130.35ng/mL had a sensitivity of 85.7%, a specificity of 94.1%, AUC of 0.96; NT-proBNP value in predicting heart failure events at the cut- off point 10754.5pg/mL had sensitivity of 85.7%, a specificity of 96.1%, AUC of 0.97. Conclusion: Quantification of serum NGAL and NT-proBNP help prognostic heart failure events in patients with the acute coronary syndrome.