Évaluation post-transplantation précoce de la dysfonction aiguë du greffon rénal

Abstract

AbstractKidney transplantation is the best option in the treatment of end-stage kidney disease. Early acute kidney transplant dysfunction is a common complication that corresponds to acute renal failure (AKI) postoperatively after renal transplantation. When it occurs, it favors acute rejection and chronic dysfunction of kidney transplant. Incidence of this complication is constantly rising due to the increased use of grafts from extended criteria donors and from donors after circulatory death. This acute renal failure clinically results in a persistent elevation of serum creatinine and possibly a decrease in diuresis and the need for dialysis during the first postoperative week. However, these signs of renal damage are mostly inefficient and lead to a late diagnosis, limiting treatment efficiency. Therefore, it is essential to develop and use new methods for evaluating acute renal damage early after kidney transplantation. This review explores the various established or developing diagnostic modalities for early AKI after kidney transplantation, whether glomerular filtration rate (GFR) assessment methods or other approaches.