Évaluation du mercury 16 (nova biomedical) : application aux profils d'urgence et de routine sur sang total et urine en néphrologie

Abstract

The aim of this work was to assess the performances of Mercury 16 (sodium, potassium, chloride, total CO 2, glucose, urea, creatinine and hematocrit on whole blood, plasma, serum, urine, dialysate and cerebrospinal fluid) in following critical situations: use without formation, use with minimal maintenance and short laboratory responses time (less than 5 min.) on whole blood and urine and on icteric samples. The results obtained on whole blood and plasma were quite similar and the correlations between Mercury 16 - whole blood, CX7 Delta (Beckman) and STKS (Coulter) before and after dialysis (30 patients) were highly significant. Considering the well known potential bilirubin interference on glucose, creatinine and blood urea nitrogen determinations, our study showed the insensitivity of Mercury 16 to bilirubin (concentrations up 200 μmol/L to 700 μmol/L as total bilirubin). The correlations between Mercury 16 and CX7 Delta in 42 urine were highly significant. Finally, considering the analytical specifications, the short and easy maintenance, the management of analytical and patient data and reagents, the turnaround time (less than 2 min. for all mesured tests), the possibility of a link (direct or via a specific station) to central laboratory system, Mercury 16 is well adapted to any critical care situations and so, to point care of testing, in agreement with GBEA and Société française de biologie clinique recommendations.