Évaluation du handgrip préradiochimiothérapie des patients présentant un cancer des voies aérodigestives supérieures

Abstract

IntroductionThe updated diagnosis criteria for adult undernutrition introduced assessment of muscle mass and/or muscle function. As undernutrition is a factor in the interruption of radio-chemotherapy treatments for head and neck cancer, we evaluated the association between pre-therapeutic muscle function according to handgrip strength and treatment interruptions. Materials and methodsAncillary study of an observational, mono-centric, prospective cohort evaluating the benefit of systematic, global and early supportive care in patients with head and neck cancer before radio-chemotherapy concomitant. Were included patients for whom radio-chemotherapy concomitant was being considered for radical treatment of head and neck cancer and who had a pre-therapeutic handgrip test. ResultsThirty-nine patients were included from July 2019 to February 2020. Nine patients were undernourished and three had pathological handgrip strength. Handgrip test permitted to reclassify three patients as undernourished. Radiotherapy discontinuation was significantly associated with a pathological pre-therapeutic handgrip strength (P=0.0359). No association was found for discontinuation of chemotherapy (P=1). ConclusionPre-therapeutic handgrip test for patients with head and neck cancers is of interest on the oncological treatments choice regarding toxicities risk that may lead to treatment discontinuation.