Abstract
The Cobas Integra 700 is a closed multiparametrical analyser with captive reagents allowing to test usual biochemistry parameters (electrolytes, substrates and enzymatic activities), but also therapeutic drugs, drugs of abuse, toxics and specific proteins. During our experimental work, we evaluated the analytical performances of the Cobas Integra 700 according to the Société française de biologie clinique (SFBC) technique validation protocol (Valtec 97) for the following analytes: sodium, potassium, iron, urea nitrogen, creatin kinase, amikacin, IgG, albumin and C-reactive protein (CRP) in blood, sodium, potassium, creatinine and proteins in urine. The results we obtained allow to confirm the excellent analytical performances regarding imprecision and operational characteristics. On the other hand, concerning some analytes, we noticed an inaccuracy with the selected comparison techniques, especially for CRP, urine sodium and proteins. In conclusion and considering its practicability (automated daily servicing, software user-friendliness, automated reagents reconstitution…), the Cobas Integra 700 seems to us well suited for biochemistry laboratories performing from 1,500 to 3,000 daily tests.
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