Évaluation de la réponse antipyrétique à 30 minutes de l'ibuprofène suspension aux urgences pédiatriques

Abstract

The ibuprofen, a synthesis inhibitor of prostaglandin, has antipyretic effectiveness considerably studied and proved in the child. Objective. – The purpose of this study is to rate the precocious, total antipyretic effectiveness and in high fever ( T ≥ 39.5 °C), of the pediatric population attending a children emergency unit. It is about a prospective study of 1120 feverish children collected between 1st August and 31st December 2001, at the Casablanca children emergency unit. The criteria of inclusion consisted of, the age between 6 months and 12 years old, a temperature ≥ 38 °C and the absence of previous use of antipyretics. The rectal temperature has been taken by a mercury thermometer. The posology used was about 10 mg/kg once. The rectal temperature has been controlled 30 min after the administration of the ibuprofen. Results. – The mean age was 40.8 months and the average of initial temperatures was 38.76 °C. The average of temperature decreased from 38.76 to 38.15 °C in 30 min ( P < 0.05). In the group of children ( n = 203) who suffered from high fever ( T ≥ 39.5 °C), the average of temperatures went down from 39.83 to 38.93 °C in 30 min ( P < 0.05). We did not notice any difference of effect concerning age. Conclusions. – This study confirms the effectiveness and the precocity of the antipyretic effect of the pediatric suspension ibuprofen in a children emergency unit.