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Abstract
We investigated the cardioprotective effect of Mareya micrantha (Euphorbiaceae) from the dosage of 3 biochemical markers. It is a plant traditionally used as laxative, antibacterial and for abortion affections in Côte d’Ivoire and in other countries in West Africa. Increasing doses of aqueous crude extract of Mareya micrantha were injected to various rabbits of different batches. Then we evaluated the variation of the serum activities of glutamo-oxaloacetic transaminase (GOT), lactate-deshydrogenase (LDH) and creatinephosphokinase (CPK). The statistic analysis of results shows a reduction of serum activities of CPK and LDH (P < 0.05) but it indicates an insignificant variation of the serum activity of GOT (P > 0.05). In conclusion, we can say the extract of Mareya micrantha with the dose of 100 mg/kg of body weight during 4 weeks is well tolerated by heart and it also may have heart protector effect in rabbits.
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