Abstract
Researchers at the University of Maryland School of Medicine, Baltimore, and other centers analyzed the records of 17 children undergoing liver transplantation (LT) for valproic acid-associated liver failure (VPA-ALF) and 98 with ALF caused by other drugs (non-VPA-drug-induced acute liver failure [DIALF].
Highlights
The onset and progression of cardiac involvement in juvenile neuronal ceroid lipofuscinosis (Batten disease) are studied in 29 children and adolescents with genetically verified disease at Aarhus University Hospital, Skejby, Denmark
Gingival hyperplasia associated with phenytoin treatment of epilepsy is reported in as few as 3% of cases (Lennox WG, 1940) to as many as 78% (Gardner AF et al, 1962)
Hyperglycemia induced by phenytoin, an effect discovered in our neurology research laboratories at Children's Memorial Hospital (Belton NR et al Epilepsia 1965;6:243-249), warrants investigation as a potential contributing cause of gingival inflammation and overgrowth
Summary
The onset and progression of cardiac involvement in juvenile neuronal ceroid lipofuscinosis (Batten disease) are studied in 29 children and adolescents with genetically verified disease at Aarhus University Hospital, Skejby, Denmark. Gingival hyperplasia associated with phenytoin treatment of epilepsy is reported in as few as 3% of cases (Lennox WG, 1940) to as many as 78% (Gardner AF et al, 1962). Hyperglycemia induced by phenytoin, an effect discovered in our neurology research laboratories at Children's Memorial Hospital (Belton NR et al Epilepsia 1965;6:243-249), warrants investigation as a potential contributing cause of gingival inflammation and overgrowth.
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