Abstract
A 12-year-old girl with complex partial seizures who had pubertal arrest of both growth and secondary sexual development while receiving VPA is reported from the Department of Pediatrics, Wright State University, Dayton, OH and the University of Iowa, Iowa City, IA.
Highlights
The clinical, pathologic and etiologic characteristics of thalamic lesions in infancy are reviewed in an editorial
In one pattern of thalamic hemorrhagic or asphyxial insult, the neurologic abnormalities presented at birth
In almost 2/3 of term infants with intraventricular hemorrhage the primary lesion is in the thalamus
Summary
The clinical, pathologic and etiologic characteristics of thalamic lesions in infancy are reviewed in an editorial. During the past 30 years, two distinct patterns of thalamic hemorrhagic insult in infants have been described, with different etiology, clinical presentation, scan appearance and prognosis. Most affected infants were born at term, the thalamic changes were always bilateral, and the MRI was the most sensitive technique in diagnosis.
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