Abstract
A mentally retarded 30-year-old woman with partial trisomy of chromosome 9, suffering from epilepsy since age 11 months, developed systemic lupus erythematosus after one year of treatment with valproate (VPA) and ethosuximide (ESM) at the Clinica Neurologica, Universita di Roma Tor Vergata, Italy.
Highlights
The patient was maintained on ESM without relapse
PET BITEMPORAL HYPOMETABOLISM IN INFANTILE SPASMS A group of 18 infants with infantile spasms and a common metabolic pattern on positron emission tomography (PET) is reported from the Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI
Children with infantile spasms associated with bitemporal glucose hypometabolism on PET appear to comprise a homogeneous group having a poor prognosis, delayed development and severe dysphasia, and autism
Summary
PET BITEMPORAL HYPOMETABOLISM IN INFANTILE SPASMS A group of 18 infants (age range, 10 mo to 5 yr) with infantile spasms and a common metabolic pattern on positron emission tomography (PET) is reported from the Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI. VALPROATE-INDUCED LUPUS ERYTHEMATOSUS A mentally retarded 30-year-old woman with partial trisomy of chromosome 9, suffering from epilepsy since age 11 months, developed systemic lupus erythematosus after one year of treatment with valproate (VPA) and ethosuximide (ESM) at the Clinica Neurologica, Universita di Roma Tor Vergata, Italy. When prednisone 1 mg/kg/day was administered and VPA gradually discontinued, clinical remission occurred within 10 days. The patient was maintained on ESM without relapse.
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