Abstract
Valproate-induced hyperammonemic encephalopathy (VHE), predisposing causes, clinical, laboratory, and EEG findings, and therapy are reviewed from the Hospital del Mar, Barcelona, Spain.
Highlights
The time taken to develop intractability of epilepsy was determined prospectively in a cohort of 613 children followed in the Connecticut Study for a median of 9.7 years and reported by researchers from Northern Illinois University, DeKalb, IL; University of California Los Angeles, CA; Yale Medical School, New Haven, CT; and Albert Einstein College of Medicine, Bronx, NY
Intractability varied with the epilepsy syndrome and was delayed more often in focal than catastrophic epilepsies
Valproate-induced hyperammonemic encephalopathy (VHE), predisposing causes, clinical, laboratory, and EEG findings, and therapy are reviewed from the Hospital del Mar, Barcelona, Spain
Summary
The time taken to develop intractability of epilepsy was determined prospectively in a cohort of 613 children followed in the Connecticut Study for a median of 9.7 years and reported by researchers from Northern Illinois University, DeKalb, IL; University of California Los Angeles, CA; Yale Medical School, New Haven, CT; and Albert Einstein College of Medicine, Bronx, NY. Delayed intractability was defined as 3 or more years after epilepsy diagnosis. Intractability was delayed in 26 (31.3%) children meeting stringent and in 39 (27.5%) meeting the 2-drug definition.
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