Abstract
Our purpose was to assess the contribution of efavirenz and nevirapine plasma concentrations in the assessment of self-reported adherence and punctuality of appointments to take the drugs. Adherence was assessed using questionnaires and plasma concentrations of efavirenz and nevirapine were determined. Patients received efavirenz or nevirapine in combination with two nucleotides reverse transcriptase inhibitors. Among the 45 enrolled patients, 7 were considered non-adherent according to the questionnaires, 17 regarding pharmacy appointments and 5 according to the plasma levels of efavirenz and nevirapine. 3.3% participants had detectable viral loads. Cross-validation between patients'self-reports and pharmacy appointments can improve the measurement of adherence to antiretroviral therapy.
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