Abstract
IntroductionThe success in the surgical management of hyperparathyroidism has conventionally required a bilateral neck exploration. The intraoperative monitoring of intact parathyroid hormone (PTHi), allows a less extensive procedure by confirming the complete removal of hypersecreting tissue. MethodsPlasma samples were obtained from 32 consecutive patients before and 10 minutes after removal of abnormal parathyroid tissue. PTH was measured with a modifie immunochemiluminometric assay with a short incubation time and the results made available in 15 minutes. ResultsPTHi decreased by at least 60% in 30 of 32 cases. A single adenoma was removed in 26 cases, and multiple hyperplastic glands in 4 cases. The two cases in which PTHi fell <60% were diagnosed as hyperplasia. PTHi decreased > 60% after the removal of the remnant hyperplastic glands. ConclusionsThe rapid PTHi assay had excellent analytical performance and predicted the success of parathyroid surgery.
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