Abstract
With chronic or subchronic lead exposure, approximately 90% of the body burden of lead is in the skeleton. This large fraction of the total body burden has a major influence on the overall kinetics of lead disposition in the body. In studies of whole body lead metabolism, knowledge of the total skeletal burden is important, e.g., in studies of the mobilization of lead by chelating agents. The total skeletal burden is rarely measured directly. Rather, single bones are used as surrogates for the total skeleton. The present study was undertaken because there is no published information as to how representative the lead concentration in single bones is vis-a-vis the rest of the skeleton. The concentrations and amounts of lead in pairs of femurs and pairs of tibias were compared to the concentration and amount in the rest of the skeleton of mice receiving a course of i.p. lead injections followed in some groups by a course of treatment with dimercaptosuccinic acid (DMSA) and of two prodrugs thereof. The concen...
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