Abstract
BackgroundThis study aimed to assess the validity of the EQ-5D-5L in respondents with self-reported diabetes coming from a representative general population survey.Methods2974 respondents from the general adult population of Poland, chosen with multi-stage random sampling, were surveyed with HRQoL instruments (EQ-5D-5L, EQ VAS, SF-12, EQ-5D-3L) and a screening question about diabetes. To obtain EQ-5D index values, we used country-specific Polish value sets. We compared the instruments in terms of the ceiling effect, discriminatory power and frequency of individual health states. We evaluated construct validity in terms of known-groups validity and convergent validity of EQ-5D-5L dimensions and index values with other HRQoL measures.ResultsIn respondents with diabetes (n = 247), the percentage reporting 'no problems' with EQ-5D-3L was reduced by 34.5% with the use of EQ-5D-5L (from 14.2% to 9.3%, respectively). A significant improvement in informativity was noticed in mobility and pain/discomfort dimensions (a relative increase of 23.1% and 22.7%, respectively). Known-groups construct validity analysis confirmed prior hypotheses—index scores were higher in the following groups: younger respondents, males, those taking no medication or oral antidiabetic drugs, and respondents with higher levels of education. The convergence between related EQ-5D-5L and EQ-5D-3L or SF-6D dimensions was stronger than between unrelated dimensions. The Bland–Altman analysis showed a mean difference between EQ-5D-5L and EQ-5D-3L, SF-6D, EQ VAS/100 index scores of 0.047, 0.165 and 0.231 respectively.ConclusionsOur results support the validity of the EQ-5D-5L descriptive system and EQ-5D-5L index, based on the directly measured value set in respondents with self-reported diabetes coming from the general population.
Highlights
This study aimed to assess the validity of the EQ-5D-5L in respondents with self-reported diabetes coming from a representative general population survey
We evaluated construct validity in terms of known-groups validity and convergent validity of EQ-5D-5L dimensions with SF-12 domains, SF-6D or EQ-5D-3L dimensions, as well as the convergence of EQ-5D-5L index with EQ-5D-3L, SF-6D indexes and EQ Visual analogue scale (VAS)
From April 2014 to June 2014, 2974 respondents from the general population of Poland were surveyed with health-related quality of life (HRQoL) instruments and a screening question about diabetes [14]. 255 (8.6%) individuals self-reported diagnosis of diabetes
Summary
This study aimed to assess the validity of the EQ-5D-5L in respondents with self-reported diabetes coming from a representative general population survey. Complications and treatment of the disease reduce health-related quality of life (HRQoL) [1, 2]. This effect can be measured with numerous disease-specific. Assessment within a multi-country study involving patients with eight chronic conditions demonstrated several advantages of the new version: a reduced ceiling effect, improved discriminatory power and convergent validity [10]. These findings were confirmed by a recent review [11]
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