Validation study of the post-operative mortality risk score after liver resection for perihilar cholangiocarcinoma

Abstract

Background: A post-operative mortality risk score (POMRS) for perihilar cholangiocarcinoma (PHCC) has recently been published (Wiggers et al., J Am Coll Surg, 2016). In this report, the predicted mortality was 2% in the low-risk, 11% in the intermediate-risk, and 37% in the high-risk groups. The purpose of our study was to validate the previous study results in our department. Methods: POMRS was calculated for 203 PHCC patients who had undergone major hepatectomy in our department using the five clinical characteristics from the previous study, which included 287 patients. Results: The median age of the patients was 68 (41–86) years. Patients with preoperative cholangitis, future liver remnant (FLR) <30%, incomplete biliary drainage + FLR <50%, and portal vein resection were 37.4%, 1.4%, 0%, and 52.7%, respectively. The overall post-operative mortality rate was 6.4%. The mortalities in low-risk (n=47), intermediate-risk (n=99), and high-risk (n=57) patients were 2.1%, 7.1%, and 8.8%, respectively. There were no significant differences in mortality among these three groups (p=0.224). Conclusion: There were no significant differences in the POMRS among low-risk, intermediate-risk, and high-risk patients in our department.