Abstract
8116 Background: NSCLC is the most common cause of BM and GPA is used as a prognostic index (PI) for BM. We evaluated its validity in a contemporary large cohort treated at a single tertiary care institution. Preliminary data was presented at ASCO 2013. Methods: IRB approved. NSCLC BM treated between 2000 and 2012 was identified from the Cleveland Clinic Brain Tumor and Neuro-Oncology Center’s database. OS from the diagnosis of NSCLC BM was the primary end point.Cox proportional hazards models were used for data analysis. Results: 958 (54% male) patients were included for final analysis. Median age at BM diagnosis was 62 years (29-92). Karnofsky performance scale (KPS) was 90-100 in 345 (39%), 70-80 in 415 (47%) and 5 in 136 (14%) patients. Initial therapy included stereotactic radiosurgery (SRS) in 186 (20%) patients, whole brain radiation (WBRT) in 420 (44%), surgery (S...
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