Abstract
Introduction Symptoms typically associated with polycystic ovary syndrome (PCOS) such as oligo/ amenorrhoea, hirsutism, obesity, subfamily lead to a significant reduction in quality of life (QOL). At present, no validated questionnaire exists to measure the QOL of women with PCOS. The study was carried out to validate WHOQOLBREF before its application to assess quality of life in women with PCOS in Sri Lanka. Methodology The WHOQOL-BREF was validated on 130 women with PCOS attending an endocrine clinic at a tertiary care hospital and 130 community controls. Both convergent and discriminant validity of WHOQOL-BREF were measured simultaneously using the Multitrait-Multimethod Matrix technique in comparison with SF 36. Confirmatory factor analysis using principal component analyses was performed 10 test the construct validity. Reliability was measured by assessing internal consistency and Lest-retest reliability. Results Good convergent and discriminant validity was demonstrated by the WHOQOL-BREF for similar and different scales respectively in comparison with SF-36. Internal consistency measured using Cronbach's alpha exceeded Nunnaly's criteria of 0.7 for all except the social relationship domain in both groups while the test retest reliability measured using Pearson's correlation coefficients exceeded >0.7 (p Conclusions WHOQOL-BREF was found to be a valid and a reliable tool to assess QOL of women with PCOS. It showed good convergent validity, discriminant validity and reliability in all except the social relationships domain.
Highlights
Symptoms typically associated with polycystic ovary syndrome (PCOS) such as oligo/ amenorrhoea, hirsutism, obesity, subfenility lead to a significant reduction in quality of life (QOL)
Literature reveals that limited re.search had been carried out to assess the impact that symptoms of PCOS have upon quality of life (QOL) of women with the condition (I)
WHOQOL-BREF contains four domains related to quality of life (QOL) i.e. physical health, psychological health, social relationships and environment and one facet on "overall quality of life and general health"
Summary
Symptoms typically associated with polycystic ovary syndrome (PCOS) such as oligo/ amenorrhoea, hirsutism, obesity, subfenility lead to a significant reduction in quality of life (QOL). The study was carried out to validate WHOQOL BREF before ilS application to assess quality of life in women with PCOS in Sri Lanka. Methodology The WHOQOL-BREF was validated on 130 women with PCOS attending an endocrine clinic at a teniary care hospital and 130 community controls. Both convergent and discriminant validity of WHOQOL-BREF were measured simultaneously using the Multitrait-Multimethod Mairix technique in comparison with SF 36. At present no validated instrument is available to measure QOL of women with PCOS The instruments such as the Nottingham Health Profile that mea.5ure impairment of daily activities and disability or functional status, do not assess QOL per se (2). Each question assesses QOL in respect of the preceding 2 weeks (3)
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