Validation of warfarin pharmacogenetic algorithms in 586 Han Chinese patients.

Abstract

To compare the accuracy of the nine selected algorithms for predicting warfarin dose with 586 Han Chinese patients. Genotyping of VKORC1 1639G>A, CYP2C9*2 and CYP2C9*3 variants was performed. Both the mean absolute error and ideal estimation value were used for comparison. The top three performers were from East Asians. The algorithms from Caucasians generally performed better in the medium-dose subgroup (>3 and <7 mg/day), while the algorithms from East Asians generally performed better in the low-dose subgroup (≤ 3 mg/day). None of the algorithms performed well in the high-dose subgroup (≥ 7 mg/day). Algorithms built for specific ethnic groups and preassigned-dose groups are suggested for better prediction.