Abstract
Objective: The Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ) is intended to measure the impact of children's asthma on their parents/caregiver's QoL. However, there are no formal validation studies of the Spanish version of PACQLQ. Methods: In a prospective cohort validation study, asthmatic children aged between 7 and 17 years and their parents, attended both a baseline and a follow-up visit 2–6 weeks later. In these two visits, we gathered the necessary data for assessing the criterion validity, construct validity, test–retest reliability, sensitivity to change, internal consistency and usability of the PACQLQ. Results: At baseline, PACQLQ scores were significantly different between patients with controlled, partly controlled and uncontrolled asthma (median [IQR] 78.0 [61.0–85.0], 71.0 [37.0–76.0] and 48.0 [40.7–55.0], respectively, p < 0.001), and also between patients for whom this visit resulted in a step-up versus no change or a step-down in therapy (50.0 [40.0–60.0] versus 78.0 [61.0–85.0]; p < 0.001). PACQLQ scores at baseline were significantly lower than those obtained in the follow-up visit in patients with change for the better in the global rating of change questionnaire (median [IQR] 50.0 [42.5–56.0] versus 80.0 [78.5–85.0]; p < 0.001). The intraclass correlation coefficient of the measurements was 0.839 (95%CI: 0.735–0.902). The Cronbach α was 0.914 for the questionnaire as a whole. Conclusions: The Spanish version of the PACQLQ has adequate construct validity, adequate sensitivity to change, good internal consistency, excellent test–retest reliability and good usability when employed in children aged between 7 and 17 years with physician-diagnosed asthma.
Highlights
Childhood asthma is recognized as being the most common chronic disease among children and a major public health problem in the US as well as in many other countries, such as Colombia [1,2]
At baseline, Pediatric Asthma Caregiver’s Quality of Life Questionnaire (PACQLQ) scores were significantly different between patients with controlled, partly controlled and uncontrolled asthma, and between patients for whom this visit resulted in a step-up versus no change or a step-down in therapy (50.0 [40.0–60.0] versus 78.0 [61.0–85.0]; p
The Spanish version of the PACQLQ has adequate construct validity, adequate sensitivity to change, good internal consistency, excellent test–retest reliability and good usability when employed in children aged between 7 and 17 years with physician-diagnosed asthma
Summary
Childhood asthma is recognized as being the most common chronic disease among children and a major public health problem in the US as well as in many other countries, such as Colombia [1,2]. In recent years, there has been an increasing amount of literature that have shown that childhood asthma has impact on patient, and affects the quality of life (QoL) of the family, especially the primary caregiver [5,6]. Spanish is one of the most widely spoken languages in the world with nearly 500 million native speakers [18], and the official language of two of the four countries with the highest prevalence of pediatric asthma in the entire world [19] In this context, there is a critical need for additional validation studies of the questionnaire that further examine its measurement properties in Spanish-speaking populations
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