Validation of the kidney donor profile index (KDPI) for deceased donor kidney transplants in China

Abstract

BackgroundThe kidney donor profile index (KDPI) evaluates kidney donor's age, height, weight, ethnicity, cause of death, high blood pressure, diabetes, exposure to hepatitis C and estimated glomerular filtration (eGFR). Kidneys with lower KDPI scores are expected to function longer that those with higher KPDI values. The applicability of KDPI score in Chinese kidney transplant donation has not yet been validated. This study evaluated the prognostic value of KDPI score in Chinese kidney transplant patients. MethodsA retrospective analysis was conducted on 184 deceased donors and 353 corresponding kidney transplant patients at the Organ Transplantation Department of Renmin Hospital of Wuhan University between 2018 and 2021. The donors and recipients were stratified into four groups based on their KDPI score: KDPI 85–100, KDPI 60–84, KDPI 21–59, and KDPI 0–20. ResultsAs expected, the KDPI 85–100 group was associated with a poor short-term renal function (both postoperative creatinine and eGFR with P > 0.05), a higher incidence of delayed graft function (DGF; 25.5% for KDPI 85–100 group vs. 10.2% for KDPI 60–84 group vs. 5.4% for KDPI 21–59 group vs. 0 for KDPI 0–20 group, all P > 0.05). Furthermore, the same groups showed worse 3-year patient survival rate: 86.3% for KDPI 85–100 group vs. 97.01% for KDPI 60–84 group vs. 97.83% for KDPI 21–59 group vs. 100% for KDPI 0–20 group, all P > 0.05); and renal survival rate: 82.6% for KDPI 85–100 group vs. 92.99% KDPI 60–84 group vs.97.83% for KDPI 21–59 group vs. 100% for KDPI 0–20 group, all P > 0.05). Our analysis showed that the KDPI score had a good predictive value for the survival of kidney transplants and patients in our center (area under the curve: 0.728 and 0.76, P > 0.05). ConclusionWe recommend that the KDPI scoring system can be employed as an effective tool to predict kidney transplantation outcomes in deceased donation in China.