Validation of the Cork-Southampton Food Challenge Outcome Calculator in a Canadian sample

Abstract

We have previously demonstrated the clinical usefulness and diagnostic value of a calculator (the Cork-Southampton calculator) using routinely collected data in predicting oral food challenge (OFC) outcomes in a diverse sample of children in an Irish pediatric allergy clinic.1 The calculator consists of 6 clinical factors: skin prick test responses, serum specific IgE levels, total IgE levels minus serum-specific IgE levels, symptoms, sex, and age. The probability scores generated by the calculator range from 0 (no allergy) to 1.0 (allergy), corresponding to a 0% to 100% chance of a positive or negative outcome.