Abstract
Objective: A simple and sensitive extractive visible spectrophotometric method is developed for the assay of triprolidine hydrochloride using sodium nitroprusside.
 Methods: Based on color development with amino groups, presence, which is basic, may be due to the formation of inner complex replacing H2O by the tertiary amino group present in the drug.
 Results: The colored products exhibit absorption λmax at 447 nm. Regression analysis of Beer–Lambert plots showed good correlation in the concentration ranges (40–240) μg/ml and correlation coefficients are 0.994. The Sandell’s sensitivities 2.6373×10−2 (1 mole cm−1) and molar absorptivity value are 1.1938×104 (g cm−2). Recovery studies are found to be 99.708–99.786.
 Conclusion: The method can be applied successfully for the estimation of the drug in the presence of other ingredients that are usually present in formulations.
Highlights
Triprolidine hydrochloride (TPH) is chemically 2-[(1E)-1-(4methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl] pyridine (Fig. 1)
A literature survey revealed that few analytical methods have been reported for the determination of TPH in plasma using thin-layer chromatography [3] simultaneous determination of TPH with other anti-histamines [4,5,6] other agents [7,8] reported
Few methods have been developed for the determination of triprolidine by high-pressure liquid chromatography (HPLC) [9] and spectrophotometric method [10]
Summary
Triprolidine hydrochloride (TPH) is chemically 2-[(1E)-1-(4methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl] pyridine (Fig. 1). This is an anti-allergic, histamine H1 antagonist that blocks the action of endogenous histamine, which subsequently leads to temporary relief of negative symptoms brought on by histamine. It is used for the treatment of seasonal or perennial allergic rhinitis or non-allergic rhinitis, conjunctivitis, and mild urticarial and angioedema [1]. The most common side effects are sedation, dizziness, coordination, gastrointestinal disturbances, nausea, vomiting, and diarrhea It may produce blurred vision, dryness of mouth, tight of the chest, and blood disorders, including agranulocytosis and hemolytic anemia [2]. TPH is usually administered in combination with dextromethorphan and/or phenylpropanolamine and with paracetamol [16]
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