Abstract
Abstract : The major goal of this project was to develop a clinical trial focused on the validation of diagnostic and prognostic utility of quantitative analysis of telomerase activity in exfoliated cells in urine as a molecular marker and clinical tool for: 1) noninvasive early detection of prostate cancer; and 2) determination of indolent asymptomatic carcinomas that have potential to develop into invasive disease and require treatment. We report here that our research and clinical teams are completely ready to carry out the proposed clinical trial. We have developed and optimized all research and clinical protocols. We have prepared all material resources for large-scale complex analysis of telomerase activity in patients exfoliated cancer cells. We have established a reliable crosscommunication between our clinical and research personnel.
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