Abstract
Intravenous delivery is the fastest conventional method of delivering drugs to their targets in seconds, whereas intramuscular and subcutaneous injections provide a slower continuous delivery of drugs. In recent years, nanoparticle-based drug-delivery systems have gained considerable attention. During the progression of nanoparticles into the blood, the sound waves generated by the particles create acoustic pressure that affects the movement of nanoparticles. To overcome this issue, the impact of sound pressure levels on the development of nanoparticles was studied herein. In addition, a composite nanostructure was developed using different types of nanoscale substances to overcome the effect of sound pressure levels in the drug-delivery process. The results demonstrate the efficacy of the proposed nanostructure based on a group of different nanoparticles. This study suggests five materials, namely, polyimide, acrylic plastic, Aluminum 3003-H18, Magnesium AZ31B, and polysilicon for the design of the proposed structure. The best results were obtained in the case of the movement of these molecules at lower frequencies. The performance of acrylic plastic is better than other materials; the sound pressure levels reached minimum values at frequencies of 1, 10, 20, and 60 nHz. Furthermore, an experimental setup was designed to validate the proposed idea using advanced biomedical imaging technologies. The experimental results demonstrate the possibilities of detecting, tracking, and evaluating the movement behaviors of nanoparticles. The experimental results also demonstrate that the lowest sound pressure levels were observed at lower frequency levels, thus proving the validity of the proposed computational model assumptions. The outcome of this study will pave the way to understand the interaction behaviors of nanoparticles with the surrounding biological environments, including the sound pressure effect, which could lead to the useof such an effect in facilitating directional and tactic movements of the micro- and nano-motors.
Highlights
In recent years, nanoparticles have attracted considerable interest for various restorative applications
The proposed structure of the nanoparticle drug and the related computational model are described in detail
Ultrasonic techniques for detecting and tracing nanoparticles could be enhanced with the rapid growth of using microbubble contrast agents, and their second generation that can be filled with heavy molecular weight particles could be combined with various nanoparticles, which enhances the capabilities of targeting specific tissues inside the human body [26]
Summary
Nanoparticles have attracted considerable interest for various restorative applications. Under a rotating attractive field (AMF), certain magnetic nanoparticles (MNPs) can create heat through hysteresis that can be exploited to treat malignant growth. MNP heating has been presented as a strategy for remote neuromodulation [1]. The destabilizing particles are added to earlier nanoparticle during spilling of the scattering through the acoustic gap; the instigated collection prompts the arrangement of fundamentally slender microstructures [2]. The hydrodynamic vehicle of ring polymers through adjusted channels is expected on the ring topology [3]. Geometric scaling depends on the ratio of the maximum radii of air pockets in the two setups, and fluid element scaling follows the Rayleigh scaling [4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
