Abstract
BackgroundMurraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems.MethodsAqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trachea and aorta) to detect the possible presence of spasmolytic activity. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system.ResultsApplication of the extract of Mp.Cr relaxed spontaneous and high K+ (80mM)-induced contraction in rabbit jejunum preparation. Because it shifted the CRCs (Calcium response curve) towards the right side so the possible blockade was of calcium channel similar to verapamil. In rabbit trachea, extract of Mp.Cr produced relaxation of carbachol and high K+ induced contractions. When plant extract was checked further on isolated aorta for its possible vasodilator effect, it caused relaxation of phenylephrine and high K+-induced spastic contractions at different doses.ConclusionThese results indicate that Murraya paniculata shows anti-spasmodic, bronchodilator and vasodilator activity facilitated through Ca++ antagonist mechanisms.
Highlights
Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders
Pakistan is known as land of spices and many indigenous spices are being used as medicinal food here
Mp.Cr caused relaxant effect on low K+ (25 mM) induced spastic contraction (0.3 mg/ml) jejunum preparation whereas it caused a complete relaxation of high K+ (80 mM) induced contraction (0.3–1.0 mg/ml) with EC50 0.2723 mg/ml (95 % Cl: 0.1526–0.4859, n = 4–5)
Summary
Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems. The concept of medicinal foods and nutraceuticals is gearing momentum and people are seeking foods having health-promoting and immunity-boosting effects. Markets are booming with functional foods in various forms and at various prices. Local communities in developing countries use many indigenous foods items as medicinal food without knowing the scientific basis of their healthy effects. Pakistan is known as land of spices and many indigenous spices are being used as medicinal food here. (Rutaceae) locally known as Orange Jessamine is a commonly used spice in Pakistan. It is added to food and beverages by local
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