Abstract
BackgroundGastric cancer (GC) incidence and mortality are rapidly growing worldwide. It is estimated that more than 1,000,000 new cases are diagnosed each year, and more than 78,000 people lose their lives due to GC. The association between dietary antioxidants and GC has been shown in some studies. However, because of the discrepancy between the findings and the lack of a valid indicator, it seems necessary to design and validate the Dietary Antioxidant Index (DAI) to examine the diet's total antioxidant content. The present study aimed to survey the validity of DAI and its association with the odds of GC.MethodsIn this hospital-based case–control study, 82 patients with GC and 95 healthy controls were examined. We used a 168-item food frequency questioner to assess dietary intakes. The DAI was calculated based on the intake of vitamin A, C, E, and selenium, manganese, and zinc. We standardized each of the six vitamins and minerals by subtracting the global mean and dividing by the global standard deviation to calculate DAI. We then calculated the DAI by summing up the standardized intakes of these vitamins and minerals of the individuals with equal weight.ResultsWe observed a significant correlation between DAI and total antioxidant capacity (TAC) after controlling for age, body mass index (BMI), energy intake, smoking and fasting blood sugar, education, total fat intake, helicobacter pylori infection, total cholesterol, and saturated fatty acid (SFA) intakes. Results obtained from modeling DAI as a continuous variable in relation to GC showed a negative association after adjustment for age and in the multivariable analysis (OR = 0.64, CI = 0.43–0.95).ConclusionDAI is a valid indicator of dietary antioxidants assessments, and it can be used as a predictor of antioxidant status due to its correlation with serum antioxidant levels. The results showed that dietary antioxidants have a significant relationship with GC, which indicates the importance of antioxidants in this cancer's etiology.
Highlights
Gastric Cancer (GC) is one of the most common and pernicious malignancies globally [1]
It is estimated that each year more than 1,033,701 new cases of Gastric cancer (GC)
Controls were significantly had higher body mass index (BMI) and Dietary Antioxidant Index (DAI) scores compared to controls
Summary
Gastric Cancer (GC) is one of the most common and pernicious malignancies globally [1]. Due to the increase in the incidence and prevalence of various types of cancers, some foods and micronutrient antioxidants are considered more. Several studies have examined the association between food and micronutrients with antioxidant properties with the incidence and prevalence of various diseases [17,18,19]. Natural products play a critical role in discovering and developing numerous drugs for the treatment of various types of cancers via different mechanisms [21,22,23]. These studies have done well in cancer patients [18, 24,25,26].
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