Abstract
(1) Background: The SKT (Syndrom Kurztest) is a short cognitive performance test that consists of nine subtests and assesses deficits of memory and attention. This study was aimed at exploring the SKT target population in China and evaluating the reliability and validity of the Chinese version of the SKT; (2) Methods: A total of 1624 patients aged over 60 years old were recruited in the Sixth People’s Hospital in Shanghai. The SKT raw scores were recorded. Cronbach’s alpha coefficient was determined to assess the internal consistency reliability of the SKT. Principal factor analysis was performed to evaluate the factor structure of the SKT subtests. Correlation analyses were carried out to confirm the relationship between the modified SKT and standardized neuropsychological tests. The influence of age and educational years on SKT raw scores were detected using multiple regression analyses. Validations of the SKT subtests for detecting Mild Cognitive Impairment (MCI) from Negative Control(NC)(were determined by Receiver operating characteristic (ROC) curves; (3) Results: The internal consistency among the subtests’ scores was high: Cronbach’s α = 0.827. The SKT memory test provided a high predictive validity in detecting aMCI with a sensitivity of 90.1% and specificity of 79.3%. (4) Conclusions: Based on our experience with 1624 elderly patients in Shanghai, the Chinese version of SKT has good stability and may be a reliable and valid screening tool for detecting MCI.
Highlights
Alzheimer‘s disease (AD) has become one of the most common neurodegenerative diseases that occur with aging
The clinical development process of AD can be divided into preclinical stage, mild cognitive impairment [1] (Mild Cognitive Impairment, MCI), and dementia stage
The MCI group was significantly older than the subjective cognitive decline (SCD) group and the NC group, with significantly lower education level than the other two groups
Summary
Alzheimer‘s disease (AD) has become one of the most common neurodegenerative diseases that occur with aging. It is characterized by cognitive impairment, executive dysfunction, and personality and behavior changes. Different degrees of cognitive impairment will affect the health and quality of life of the elderly and increase the socio-economic burden on families and caregivers. The clinical development process of AD can be divided into preclinical stage, mild cognitive impairment [1] (Mild Cognitive Impairment, MCI), and dementia stage. Due to the lack of specific treatments for AD at present, early intervention in MCI or the preclinical stage is of great significance for delaying the progression of the disease and even reversing the Subtest
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