Validation of Automated Monitoring of Cardiac Output for Biventricular Pacing Optimization

Abstract

Biventricular pacing (BiVP) can increase cardiac output (CO) during acute failure of the left ventricle (LV) after cardiac surgery. This CO benefit is maximized by adjustment of atrioventricular (AVD) and interventricular (VVD) pacing delays. Real-time CO calculation could facilitate this optimization. Accordingly, we compared real-time automated analysis (AA) of CO with manual analysis (MA) in an animal model of pressure overload of the right ventricle (RV). In six anesthetized pigs, pacing leads were placed on the right atrium, RV, and LV. Complete heart block was induced with ethanol injection, and RV systolic pressure was doubled with a pulmonary artery snare. Atrioventricular pacing delay was varied over seven common values and VVD over nine, in random sequence. Two LV pacing sites (LVPS) were also tested. Aortic flow velocity, measured by ultrasonic flow probe, was integrated by AA and MA to calculate CO. Interexaminer Reliability Coefficient (IRC) was determined by Analysis of Variance (ANOVA) for two 10-second runs in each animal. Cardiac output-AVD and CO-VVD relations were similar for AA and MA. Interexaminer Reliability Coefficients were 0.997 and 0.994 for MA vs. AA. Automated analysis was available in real-time. Manual analysis was delayed at 2 hours or more. Automated analysis merits development for real-time optimization of intraoperative BiVP.