Abstract
Abstract Analysis of inorganic ions such as sodium or chloride in pharmaceutical compounds has traditionally employed ion-chromatography (IC) with conductivity detection. A new quantitative method for the determination of sodium in LY293111 sodium, a novel LTB4 receptor antagonist, using high performance liquid chromatography (HPLC) with evaporative light scattering detection (ELSD) is discussed. The separation of sodium from other ions and interferences was achieved using a Zorbax 300 SCX cation-exchange column suitable for use with organic solvents. Acceptable levels of precision, linearity, recovery, selectivity and limit of detection were achieved during the validation of the method. The results of this method were within 99.8% agreement when compared to the theoretical amount of sodium in LY293111 sodium. HPLC coupled with evaporative light scattering detection offers a practical alternative to IC using conductivity detection in pharmaceutical compounds.
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