Abstract
The aim of this study was to test whether the HPLC method for determining the n-octanol/water partition coefficient (log Pow) data of chemicals could be applied to alcohol ethoxylates (non-ionic surfactants). In order to carry out this evaluation, the range of the standard calibration line first had to be extended from 0 – 6 (OECD 117) to 0 – 9. Experimental studies confirmed that the components of alcohol ethoxylates were eluted from the HPLC column in order of their predicted hydrophobicity. The HPLC method has proved to be particularly advantageous for the determination of log Pow values for alcohol ethoxylate products as it can generate data for highly hydrophobic material (log Pow > 6) and has sufficient resolving power to separate individual alcohol components from their ethoxylated moieties. This adapted HPLC method could be used to generate data for REACH submissions.
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