Abstract
Bisphenol-A (BPA), bisphenol A glycerolate dimethacrylate (Bis-GMA), triethylene glycol dimethacrylate (TEGDMA), and urethane dimethacrylate (UDMA) are organic monomers that can be released from dental composites into the oral cavity. Over specific concentrations, they can act as endocrine disruptors or cause toxic effects. The purpose of this work is to develop and validate an analytical method to determine BPA, Bis-GMA, TEGDMA, and UDMA monomers released from synthetic dental resins in artificial saliva. The method was validated before its application to new hybrid ceramic materials used in computer-aided design and computer-aided manufacturing (CAD/CAM) restorations to determine the release of monomers in various time intervals (e.g., 24 h, and 7, 14, 30, and 60 days), both in methanolic solutions, as well as in artificial saliva. Chromatographic analysis was performed isocratically on a Perfect Sil Target ODS-3 analytical column (250 mm × 4.6 mm, 5 µm) with CH3CN/H2O, 58/42% v/v as mobile phase within 23 min. The developed method was validated in terms of selectivity, linearity, accuracy, and precision.
Highlights
Dental amalgam has been in use for repairing dental cavities for almost 150 years
There is a limited number of studies that have evaluated the leaching of computer-aided design and computer-aided manufacturing (CAD/CAM) materials [19]
bisphenol A glycerolate dimethacrylate (Bis-GMA) is the most widely used monomer in dental resin materials, and its high viscosity is responsible for the reduced degree of conversion of the monomers, which leads to its higher elution in the human body [25]
Summary
The Minamata convention for mercury release has affected the use of this traditional material due to concerns over its use and the potential release of mercury intraorally, and the environmental impact during its disposal [1]. Some of their disadvantages of dental fillings with amalgam are their metallic appearance, the high risk of tooth fracture, and the partial removal of tooth structure. All the above have led to other dental materials, such as methacrylic resins and silicate cement Those materials were not as safe as they were expected to be, raising more research in order to establish the biocompatibility and safety of resin composites [4,5]
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