Validation of a Short Food Frequency Questionnaire to Measure Dietary Intake of a Selection of Micronutrients in Oncology Patients Undergoing Systemic Therapy.

Mitali S Mukherjee,Shawgi Sukumaran,Michelle D Miller,Christopher L Delaney

doi:10.3390/nu13124557

Mitali S Mukherjee, Shawgi Sukumaran + Show 2 more

Open Access

https://doi.org/10.3390/nu13124557

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Journal: Nutrients	Publication Date: Dec 20, 2021
Citations: 2	License type: CC BY 4.0

Affiliation: Flinders University, Flinders Medical Centre

Abstract

Dietary intake, specifically consumption of anti-inflammatory micronutrients, can play a role in both cancer initiation as well as the treatment-related outcomes experienced by patients receiving systemic cancer therapy. Increasing research is being conducted to determine whether micronutrient supplementation can aid in altering the tumor microenvironment (TME), reducing inflammatory side effects and immune-related adverse events (irAEs). However, further research pertaining to the adequacy of dietary micronutrient intake is indicated in the oncology cohort. Currently, no tool measuring dietary intakes of various micronutrients exists in the oncology population. In this study, a 21-item food frequency questionnaire (FFQ) measuring intakes of 14 different micronutrients was validated using diet history as the reference method in 112 oncology patients. Bland Altman plot and Passing Bablok regression analysis were conducted to determine agreement between the two methods. The results showed adequate agreement between FFQ and diet history for 12 nutrients including copper, iron, vitamins A, E, and D, alpha linolenic acid (ALA), long-chain omega 3 fatty acids (LC n3-FA), arginine, glutamic acid, isoleucine, leucine, and valine. This 21-item FFQ, which takes an average of 10 min to complete, can be utilized as a quick screening tool to determine adequacy for 12 different micronutrients in place of a diet history.

Highlights

Cancer is the leading cause of death globally, accounting for 10 million deaths and19.3 million new cases in 2019 [1]
The results showed that participants that had a lower dietary inflammatory index (DII) score and a greater adherence to the Mediterranean diet, which is rich in antioxidants and anti-inflammatory foods, had an overall lower risk of cancer incidence [11]
A sample of 112 patients receiving chemotherapy, immunotherapy, or combined systematic cancer therapies were approached for participation via convenience sampling method at Flinders Infusion Suite, Flinders Medical Centre, Adelaide, South Australia

Summary

Introduction

Cancer is the leading cause of death globally, accounting for 10 million deaths and. 19.3 million new cases in 2019 [1]. It is established that chronic inflammation is a risk factor for cancer [2]. Cancer initiation may occur due to sustained inflammation inducing genetic instability through cytokine signaling or activation of reactive oxygen species (ROS) [3]. The mechanism of cancer-related inflammation involves intrinsic and extrinsic pathways. Oncogenes drive the transformed cells to produce cytokines, chemokines, and growth factors.

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