Validation of A New Non-invasive Tonometer for Determining Aortic Pulse Wave Velocity in Rats

Abstract

s 155 Oscillometric bSBP/bDBP was used for brachial waveform calibration. Radial and brachial waveforms were consecutively obtained with applanation tonometry.BrachialMAP(bMAP)wasderived frombrachial tonometrybyareamethod. Radialwaveformswere calibrated to bSBP/bDBPand to bMAP/bDBP; cPP values wereobtained for eachcalibrationmethod, PPawascalculated asbPP/cPP, and brachio-radial PPa was the difference between the two PPa values. On average, bSBP/bMAP/bDBP was 129/94/72 16/12/9mmHg. PPa was 1.42 0.25 when radial wave was calibrated to bSBP/bDBP, and 1.20 0.13 after calibration to bMAP/bDBP. Brachio-radial PPa was 0.22 0.17, and on average represented 52 18% of central-to-peripheral PPa. In a multivariate regression model, age, male gender, heart rate and cPP were all independent predictors of brachio-radial PPa. Conclusions: Results suggest that brachio-radial PPa may represent a significant proportion of central-to-peripheral amplification. These findings require confirmation with invasive measurements.