Abstract
In 2003 a study was published evaluating the WHO clinical case definition for paediatric HIV infection in Bloemfontein South Africa. It was found that the WHO case definition could only detect 14.5 per cent of children who were in fact symptomatic and HIV positive on age-appropriate serology testing. Following logistic regression analysis a new case definition was proposed namely that HIV is suspected in a child who has at least two of the following four signs: marasmus hepatosplenomegaly oropharyngeal candidiasis and generalized lymphadenopathy. This new case definition had a sensitivity of 63.2 per cent and a specificity of 96.0 per cent. (excerpt)
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