Validation and Reproducibility of Changes in Magnetic Resonance Imaging Radiomic Features in Response to Androgen Deprivation Therapy in Patients with High-risk Prostate Cancer

Abstract

Purpose: Biochemical response to neoadjuvant androgen deprivation therapy (nADT) predicts recurrence-free and overall survival for prostate cancer (PCa). However, PSA levels often become undetectable following nADT and may not reflect the true extent of tumour cell kill. Our previous work on magnetic resonance imaging (MRI) of high-risk patients showed significant changes in textural radiomic features in response to nADT demonstrating their potential as surrogate biomarkers [1]. We aimed to validate these changes and evaluate their reproducibility using test–retest MRI scans before and after nADT.