Abstract
Objectives: The aim of this work was to develop and validate new, simple, accurate, and selective spectrophotometric methods (derivative and derivative ratio spectrophotometric methods) for the determination of these drugs. These methods can be used as analytical tools in routine examination in quality control laboratories.
 Methods: The first method was derivative method in which the first derivative method (1D) for determination of PCM and the second derivative method (2D) for determination of CIN. The second method was the first derivative ratio spectrophotometric method (1DD) for determination of CIN and PCM.
 Results: In first method, the first derivative spectrum (1D) of PCM where PCM was determined by measuring the amplitude of the valley at 235 nm while CIN showed zero crossing spectrum, and the second derivative spectrum (2D) of CIN where CIN was determined by measuring the amplitude of the peak at 287.5 nm while PCM showed a zero value. In the second method, the first derivative ratio spectrophotometry (1DD) for CIN and PCM determination, where the amplitude at 290 and 291 nm, was selected for the determination of CIN and PCM, respectively.
 Conclusions: The developed methods were applied for the determination of the cited drugs in tablets containing binary drug mixture. The methods are simple and precise and can be used for routine analysis of the labeled drugs in combined dosage forms in quality control laboratories.
Highlights
Cinnarizine (CIN) (Fig. 1a), [1-(diphenyl methyl)-3-(4-phenylprop-2enyl)-piperazine] is a piperazine derivative that has antihistaminic (H1 blocker), calcium channel blocker, and sedative activity
The pharmaceutical dosage form was purchased from the Egyptian local market
Cinnarizine® tablets were manufactured by Arab Drug Company Cairo
Summary
Cinnarizine (CIN) (Fig. 1a), [1-(diphenyl methyl)-3-(4-phenylprop-2enyl)-piperazine] is a piperazine derivative that has antihistaminic (H1 blocker), calcium channel blocker, and sedative activity. CIN is used for the treatment of vertigo, nausea caused by Meniere’s disease and motion sickness It is used in the various peripheral and cerebral vascular disorders management [1,2]. PCM has antipyretic and analgesic effects and can be used for treatment of mild-to-moderate pain as headaches, fever, and other minor pains and aches. It is used as a main constituent in several cold medications in combination with nonsteroidal anti-inflammatory drugs [1,4]. PCM acts mainly by inhibition of prostaglandin synthesis in the central nervous system Such combination is highly effective as each drug potentiates the other in boosting brain oxygen supply
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