Abstract
A new simple, precise, accurate and selective RP - HPLC method has been developed and validated for simultaneous es timation of cinnarizine (CIN ) and d omperidone (DOM) in tablet dosage form. The method was carried out on a C - 18 (250mm × 4.6mm i.d, 5µm) column with a mobile phase consisting of m ethanol and a cetonitrile in the ratio (70:30 v/v) and flow rate of 1.0 mL min - 1 . The detection was carried out at 270 nm. The retention time for CIN and DOM were f ound to be 3.389 and 4.793 min respectively. The CIN and DOM followed linearity in the concentration range o f 40 - 160 μg mL - 1 and 45 - 105 μg mL - 1 with r 2 = 0.999. The amoun t of both drugs estimated by the proposed method was found to be in good agreement with label claim. The developed method was validated for precision, accuracy, sensitivity, robustness and ruggedness. The developed method can be used for routine analy sis o f titled drugs in combination in the tablet formulation s .
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