Abstract
A sensitive, accurate, precise and reliable HPTLC method has been proposed for determination of Ciclesonide and Fluticasone propionate - two widely used novel steroids in bulk as well as in pressurized metered dose preparations. Ciclesonide and Fluticasone propionate resolved well in toluene: ethyl acetate: formic acid (7: 3: 0.1 v/v/v) with respective R(subscript f) values 0.46 ± 0.004 and 0.43 ± 0.012 and could be scanned at 242 nm and 236 nm respectively. Linearity was observed in the range of 400-1100 ng band^(-1) for Ciclesonide and 200-1000 ng band^(-1) for Fluticasone propionate. The method was validated as per ICH guidelines and successfully applied for quantification of Ciclesonide and Fluticasone propionate in their commercial metered dose formulations. The method was found to be less time consuming as well as cost effective for routine analysis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Applied Science and Engineering
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
