Abstract
We would like to congratulate Mark Genovese and colleagues1 for their clinical report on the safety and efficacy of vagus nerve stimulation for the treatment of patients with refractory rheumatoid arthritis. This is an important study that advances the foundation for vagus nerve stimulation in activating the cholinergic anti-inflammatory pathway as a potential treatment for inflammatory disorders. The authors’ discussion of non-invasive stimulation of the vagus nerve, however, provides an inaccurate assessment of the state of the science of this approach, seeming to question the established fact that non-invasive vagus nerve stimulation adequately stimulates the vagus nerve.
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