Abstract
In a previous paper, the anatomy and physiology of the vagus nerve was discussed in an attempt to explain which vagus nerve fibers and branches are affected by clinically relevant electrical stimulation. This companion paper presents some of vagus nerve stimulation's putative central nervous system mechanisms of action by summarizing known anatomical projections of vagal afferents and their effects on brain biogenic amine pathways and seizure expression.
Highlights
OPEN ACCESSThis article may be cited as: Krahl SE, Clark KB.Vagus nerve stimulation for epilepsy:A review of central mechanisms
The first epilepsy patient was implanted with a vagus nerve stimulation (VNS) system by Penry and Dean in 1988.[38]
Several theories exist regarding the therapeutic mechanisms of VNS, but it is certain that activation of vagal afferents through electrical stimulation influences seizure-related circuitry within the brain
Summary
This article may be cited as: Krahl SE, Clark KB.Vagus nerve stimulation for epilepsy:A review of central mechanisms. Available FREE in open access from: http://www.surgicalneurologyint.com/text.asp?2012/3/5/255/103015
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