Abstract
Therapeutic options for ischaemic stroke have greatly improved with the introduction of intravenous thrombolysis in 1995 1 National Institute of Neurological Disorders and Stroke rt-PA Stroke Study GroupTissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333: 1581-1587 Crossref PubMed Scopus (9943) Google Scholar and endovascular therapy in 2015. 2 Berkhemer OA Fransen PS Beumer D et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015; 372: 11-20 Crossref PubMed Scopus (4274) Google Scholar Despite these reperfusion therapies, stroke is still one of the leading causes of disability worldwide, which emphasises the need for supplemental therapeutic strategies. 3 GBD 2016 Stroke CollaboratorsGlobal, regional, and national burden of stroke, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol. 2019; 18: 439-458 Summary Full Text Full Text PDF PubMed Scopus (1170) Google Scholar Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trialVagus nerve stimulation paired with rehabilitation is a novel potential treatment option for people with long-term moderate-to-severe arm impairment after ischaemic stroke. Full-Text PDF
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