Abstract
Objective The purpose of this study was to develop the mechanism of vacuolar H+ -ATPase regulation of vaginal microenvironment. Methods In this research, 53 women were divided into three groups. Their age, serum estradiol (E2), serum follicle stimulating hormone (FSH), vaginal pH value, and mRNA expression of vacuolar H+ -ATPase (VHA) on the ectocervical-vaginal epithelial cells were analyzed. Results ⑴ As serum E2 levels decreased, the vaginal pH values increased and VHA mRNA declined (P<0.01). ⑵ Immunohistochemistry scores decreased in the three groups. VHA expression decreased in human ectocervical-vaginal epithelial tissues except basal cells. ⑶ The expression of VHA was positive correlated with estradiol, while negative correlated with age and vaginal pH value (P<0.01). Conclusions Estradiol could regulate the genetic transcription and synthetic of VHA protein under vaginal microenvironment. Key words: Vacuolar proton-translocating ATPases/ME; Estradiol/BL; Follicle stimulating hormone/BL; Vagina/PH/UL
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